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Fibromyalgia new findings11/6/2023 ![]() As matter of fact we propose that fibromyalgia is a generalized form of reflex sympathetic dystrophy. There are important similarities between fibromyalgia and the localized painful syndrome named reflex sympathetic dystrophy. Fibromyalgia has neuropathic pain features since it is a stimulus-independent pain state accompanied by hypersensitivity to palpation (its medical term is allodynia), and abnormal sensations such as tingling, burning, or electric-shocks. This mechanism of pain is supported by our finding that norepinephrine (noradrenaline) injections induce pain in fibromyalgia patients. Exquisite tenderness at palpation (its medical term is allodynia) is a typical sympathetically maintained pain feature. ![]() This hyperactivity induces excessive norepinephrine (also known as noradrenaline) secretion, that could in turn sensitize central and peripheral pain receptors and thus induce widespread pain and widespread tenderness. After a triggering event (physical/emotional trauma, infections) relentless sympathetic hyperactivity may develop in susceptible individuals. “Fibromyalgia’s defining features (chronic widespread pain and tenderness to palpation) could be explained by the mechanism known as “sympathetically maintained pain”. This autonomic nervous system dysfunction could induce other symptoms of fibromyalgia such as irritable bowel, urinary discomfort, limb numbness, anxiety and dryness of the eyes and mouth.” At the same time, such individuals have sympathetic hypo-reactivity to stress, which could explain the profound fatigue, morning stiffness and other complaints associated to low blood pressure. This may explain the sleeping problems that the patients have. Patients with fibromyalgia lose the normal day/night cycles (circadian rhythms) and have a relentless sympathetic hyperactivity throughout 24 hours. “The results of these studies suggest that a fundamental alteration of fibromyalgia is a disordered function of the autonomic nervous system. Such findings have been confirmed by other groups of investigators.” We observed a paradoxical derangement of the sympathetic nervous system response to the upright posture. In a different study, we subjected patients with fibromyalgia to a simple stress test (to stand up). This abnormality was also evident during sleeping hours. We found that patients with fibromyalgia have relentless hyperactivity of the sympathetic nervous system. By means of portable recorders, we registered the subjects’ heartbeat for 24 hours while they followed their routine daily activities. “We studied a group of patients with fibromyalgia and compared them with healthy controls. Martinez-Lavin Fibromyalgia Research – August 2013 Obtaining Your Medical Records in the UK.Research – Dissociation and Interoception in FND.Research – Occupational Therapy Consensus Recommendations for FND.Research – Functional Neurological Disorder.Life Events and Escape In Conversion Disorder. ![]()
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